HOLLYWOOD, CA - JANUARY 25: Actor Garry Shandling at the Star On The Hollywood Walk Of Fame ceremony held on January 25, 2016
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Garry Shandling, the award-winning comedian and mastermind of the landmark HBO comedy The Larry Sanders Show, has reportedly died at the age of 66.

According to TMZ, Shandling was transported to a Los Angeles hospital on Thursday (Mar. 24) and passed away soon after. The cause of death is unknown, but Shandling was not publicly suffering from any illness.

Shandling forged a stand-up comedy career in the late 1970s and first appeared as a guest on The Tonight Show Starring Johnny Carson in 1981. It's Garry Shandling's Show, his first TV show, ran for five years on Showtime beginning in 1985, and was nominated for four Emmy awards.

Shandling launched The Larry Sanders Show in 1992, and the satire of late-night talk show stardom became a critical smash for HBO. The show became Shandling's legacy, although he also hosted the GRAMMY Awards and the Emmy Awards; starred in multiple feature films, including What Planet Are You From? and Town & Country; and penned a book, Confessions of a Late Night Talk Show Host: The Autobiography of Larry Sanders, as Sanders.