The ultimate one-hit wonder, Daniel Powter topped the Hot 100 for five weeks in 2006 with “Bad Day,” and has yet to crack the chart again.

(Note: ranking via Billboard, see their full 2006 Year-End Hot 100 here)

After scoring hits like “Gimme the Light,” “Get Busy” and “Like Glue,” Sean Paul turned up the heat (get it?!?) with this smash hit.

For her Loose reinvention, Nelly Furtado tapped Timbaland to remake her sound—and ended up scoring the defining hit of her career with this lead single.

We saw his face in a crowded place, and sent him to the top of the chart. James Blunt has since disowned his signature hit, but we never will.

A decade later, Shakira’s smooth moves and Wyclef’s cries of “No fighting!” are still quickly coming to mind.

A splash of sunshine and an inspiring ode to carpe diem, Natasha Bedingfield’s “Unwritten” was originally released in late 2004, but took two years to invade U.S. shores.

CeeLo Green and Danger Mouse, linking up with a name that’s the silliest possible Charles Barkley pun? Yep—and it was tremendous. Miss you guys, Gnarls.

The Houston hip hop movement hit a commercial peak when Chamillionaire announced, “They see me rollinnnnnn’/They hatinnnnnn’…,” with Krayzie Bone spitting just as furiously by his side.

It sounded unlike anything Justin Timberlake had ever done, effectively announced him as an adult artist and remains an iconic pop smash. “SexyBack” has a lot going for it, 10 years later.

Originally designed as a soundtrack hit for The Pink Panther, “Check On It” became so big that it was eventually placed on the non-U.S. version of Beyonce’s 2006 album, B’Day.

An enduring R&B hit, “Be Without You” earned MJB a record of the year and song of the year at the GRAMMY Awards, and won Best R&B Song and Best Female R&B Vocal Performance.

According to the Wikipedia page for “Grillz,” “The song is about grills, the cosmetic dental apparatuses.” Too true. It was also another big hit for Nelly, from his Sweatsuit album.

Along with “How To Save a Life,” The Fray cracked Top 40 radio with some tenderly crooned soft-rock, and sold a boatload of album in the process.

Slinky and sexual, “Me & U” confirmed Cassie as an R&B artist to watch, and displayed Ryan Leslie’s talents as a producer/songwriter.

How does a girl group like the Pussycat Dolls follow up the 2005 mega-hit “Don’t Cha,” featuring Busta Rhymes? Recruit another all-star MC, Snoop Dogg, for a movement-inducing follow-up.

As a hard-dancing, ultra-talented teen, Chris Brown first made his mark on a national level with the Scott Storch-assisted “Run It!”

Ne-Yo would go on to more dance floor-ready fare like “Closer” and “Let Me Love You (Until You Learn To Love Yourself),” but “So Sick” established him as a sensitive new voice in R&B.

Yung Joc would later serve as a featured artist on singles like Danity Kane’s “Show Stopper” and T-Pain’s “Buy U a Drank,” but his debut solo single remains one of his biggest successes.

Remember Rihanna? From way back in the day, right? Just kidding: As the world anxiously awaits ANTI, it’s worth revisiting one of Rih’s earliest smashes.

The winner of the 2006 Video of the Year trophy at the MTV VMAs was a crossover hit for Panic! at the Disco—who are still achieving new goals today.

(Note: ranking via Billboard, see their full 2006 Year-End Hot 100 here)