NEW YORK, NY - APRIL 20:  Director Jonathan Demme attends The Academy Museum presents 25th Anniversary event of "Silence Of T
Demme at the Academy Museum's 25th anniversary celebration of 'Silence of the Lambs' (Cindy Ord/Getty Images)

Oscar-winning director Jonathan Demme has died at age 73. IndieWire reports that he passed of heart disease complications and esophageal cancer. He'd received successful treatment in 2010 but saw a recurrence 2015. He's survived by his wife, Joanne Howard, and three children.

Demme was born Feb. 22, 1944 in Baldwin, New York. Since his directorial debut Caged Heat in 1974, he stayed perpetually busy. His Oscar came for 1991's Silence of the Lambs. He also gave us, Philadelphia (which won Tom Hanks his first Oscar in '94), The Manchurian Candidate, Married to the Mob, Rachel Getting Married and the Oprah-starring adaptation of Toni Morrison's Pulitzer-winning novel Beloved

Demme's final narrative film was 2015's Diablo Cody–written Ricki and the Flash, starring Meryl Streep as a rock star. His last feature was Justin Timberlake's Netflix concert special in 2016. He also did work with Talking HeadsNeil Young and UB40 earlier in his career.