The Ray Donovan actor/four-time Golden Globe nominee and the Birdman actress/two-time Oscar nominee split in September 2016 after 11 years together, writing in a statement:

“Over the past few months we've come to the conclusion that the best way forward for us as a family is to separate as a couple. It is with great love, respect and friendship in our hearts that we look forward to raising our children together and exploring this new phase of our relationship."

Watts and Schreiber have two sons, Sasha and Samuel.

Modern Hollywood's most glamorous romance went kaput on Sept. 20, 2016. The actors said they fell in love working together on the set of Mr. & Mrs. Smith and spent more than a decade together, caring for their six children. –Jeff Benjamin

They were the Cruel Intentions couple that defined an era, but even these beautiful blondes couldn't stay together. They were married for seven years, had two gorgeous children, but when news of their 2007 split came to surface, many of us questioned our own love lives. –Jeff Benjamin

The comedian/actor filed for divorce from his wife, the founder of two nonprofit organizations, in December 2014 after 19 years of marriage. They have two daughters together. –Zach Dionne

Two of showbiz's funniest and most charming people, Poehler and Arnett started dating in 2000, got married in '03, appeared on Arrested Development, Blades of Glory and Parks and Recreation together, had two sons, Archie and Abel, and split in 2012. We wept. –Zach Dionne

Everyone's favorite May/December romance between That '70s Show/G.I. Jane actors ended in 2011 after six years of marriage. Their divorce wasn't finalized for two years. –Zach Dionne

The American writer/director and British actress met in 2001 on the set of the Planet of the Apes remake, going on to make more than a half-dozen films together, having a son and a daughter, and spending 13 years together before separating. "Sometimes you're not meant to be forever together," Bonham Carter told Red magazine in 2015, "But that was a gift, a massive gift. We gave each other children and a lot more." –Zach Dionne

Twlight focused on the relationship of Robert Pattison as a vampire and Kristen Stewart as a wannabe vampire, and many people wanted it to be real life. But despite the are they/aren’t they relationship from 2008 to 2014, their love life will remain a fantasy. –Emilee Lindner

Even though it was well known that Ryan Gosling and Rachel McAdams hated each other on the set of The Notebook, the two made their onscreen chemistry come alive two years after filming the movie. They had an on-again/off-again relationship from 2005 to 2008. –Emilee Lindner

Unfortunately their mutual love for musicals (they starred in the Broadway production and movie version of Rent) wasn’t enough to keep this couple together. After being married for 10 years, Diggs and Menzel separated in 2013. –Bianca Gracie

One of Hollywood's modern-day royal couples, this one particularly stung as the duo had created their own production company—fittingly named Coquette Productions—which is now owned solely by Cox. The two apparently remain friendly. –Jeff Benjamin

Jennifer Aniston and Brad Pitt were Hollywood’s Golden Couple during their five-year marriage, which lasted from 2000 to 2005. The two actors met during a blind date put together by their agent, but their relationship came to a halt when Pitt started filming Mr. and Mrs. Smith, co-starring future wife Angelina Jolie. –Emilee Lindner

This couple (affectionally referred to as "Bennifer") may have only been together from 2002-04, but they managed to give us a whirlwind of huge pop culture moments. Affleck influenced one of J. Lo's best albums to date, This Is Me…Then, which was almost enough to make us forget the disastrous Gigli movie (almost).
–Bianca Gracie

These two have been together since 1998, so it was a surprise to see them break up 14 years later. Johnny and Vanessa seemed meant to be together: they’re both very good-looking and have a love for music and acting. But post-split, Vanessa’s music career continues to thrive while Johnny has tainted his own image with the recent Amber Heart drama. –Bianca Gracie

High school romance is a cruel temptress, but High School Musical romance is even more devastating: the former Disney Channel co-stars ended their five-year relationship in 2010. –Jason Lipshutz

The Vampire Diaries co-stars sunk their teeth into a real-life romance for fans to obsess over, but the couple split in 2013. One year later, they won “Best Chemistry” at the People’s Choice Awards, which is maybe the most awkward thing you can accomplish with an ex. –Bianca Gracie

Heidi and Seal renewed their vows for all seven years they were married, but in September of 2012, they announced a split. The supermodel and the "Kiss from a Rose" singer have three kids together, and Seal had adopted Klum's child from a previous relationship. Their divorce took three years to finalize. –Emilee Lindner

When Drew settled down with her art consultant beau it really seemed like the troubled-child-star-turned-Hollywood-maven had figured things out. The dude seemed incredibly normal and perfect for the former wild child, plus they had two kids together! Yet, after five years the couple filed for divorce, leading us to keep on rooting for Drew.
–Jeff Benjamin

Two of the most beautiful people in human history ended their two-year marriage/three-year relationship in 2010. "The logistics of being with another actor are challenging," Johansson reflected to Cosmopolitan in 2016. "There has to be a real understanding of how you share your time, especially when two people's careers are going at the same rate. Or even if one person is more successful than the other, that also proves challenging. There may be a competitive thing."
–Zach Dionne

Mad Men’s leading man and his girlfriend of 18 years seemed like the real deal, especially when Westfeldt stayed by Hamm’s side during his brief stint in rehab. Alas, the couple collectively broke the world’s heart with an official split in September 2015. –Brooke Bunce

"Blurred Lines" star Robin Thicke and actress Paula Patton were married for nine years before Patton filed for divorce in 2014. Months later, Thicke released an album titled Paula, with a lead single titled "Get Her Back"; the two are still not back together. –Jason Lipshutz

Gasps rang through Hollywood when the pair announced their divorce in 2014 after being married for 18 years. Thankfully the two actors, who have one daughter together, Stella Banderas, still remain friends. –Bianca Gracie

The actors spent 23 years as a couple before breaking up in 2009. They have two adult sons. "Of course you feel like a failure," Saradon told Reuters three years after the split. "It's a big deal, but again, it's an opportunity to grow." –Zach Dionne